Telescopic actions

A group action H on X is called "telescopic" if for any finitely presented group G, there exists a subgroup H' in H such that G is isomorphic to the fundamental group of X/H'. We construct examples of telescopic actions on some CAT[-1] spaces, in particular on 3 and 4-dimensional hyperbolic spaces. As applications we give new proofs of the following statements: (1) Aitchison's theorem: Every finitely presented group G can appear as the fundamental group of M/J, where M is a compact 3-manifold and J is an involution which has only isolated fixed points; (2) Taubes' theorem: Every finitely presented group G can appear as the fundamental group of a compact complex 3-manifold.Comment: +higher dimension

Probabilistic classification of acute myocardial infarction from multiple cardiac markers

Logistic regression and Gaussian mixture model (GMM) classifiers have been trained to estimate the probability of acute myocardial infarction (AMI) in patients based upon the concentrations of a panel of cardiac markers. The panel consists of two new markers, fatty acid binding protein (FABP) and glycogen phosphorylase BB (GPBB), in addition to the traditional cardiac troponin I (cTnI), creatine kinase MB (CKMB) and myoglobin. The effect of using principal component analysis (PCA) and Fisher discriminant analysis (FDA) to preprocess the marker concentrations was also investigated. The need for classifiers to give an accurate estimate of the probability of AMI is argued and three categories of performance measure are described, namely discriminatory ability, sharpness, and reliability. Numerical performance measures for each category are given and applied. The optimum classifier, based solely upon the samples take on admission, was the logistic regression classifier using FDA preprocessing. This gave an accuracy of 0.85 (95% confidence interval: 0.78–0.91) and a normalised Brier score of 0.89. When samples at both admission and a further time, 1–6 h later, were included, the performance increased significantly, showing that logistic regression classifiers can indeed use the information from the five cardiac markers to accurately and reliably estimate the probability AMI

Spherical structures on torus knots and links

The present paper considers two infinite families of cone-manifolds endowed with spherical metric. The singular strata is either the torus knot ${\rm t}(2n+1, 2)$ or the torus link ${\rm t}(2n, 2)$. Domains of existence for a spherical metric are found in terms of cone angles and volume formul{\ae} are presented.Comment: 17 pages, 5 figures; typo